| Henry A. (Heinz Alfred) Kissinger | Pretoria | Discussed Rhodesia and Namibia with Prime Minister Vorster. Met with a Rhodesian
delegation. | September 17–20, 1976 |
| Cyrus Roberts Vance | Pretoria | Discussed Rhodesia and Namibia with Foreign Minister Botha and British Foreign
Secretary Owen. | April 16–17, 1978 |
| Cyrus Roberts Vance | Pretoria | Discussed the Namibian question with South African officials. | October 14–18, 1978 |
| James Addison Baker | Cape Town, Johannesburg, Soweto | Met with President De Klerk, South African officials, and leaders of the African
National Congress (ANC). | March 22–23, 1990 |
| Warren Minor Christopher | Cape Town, Johannesburg, Pretoria | Met with President Mandela and delivered an address at the University of the
Witwatersrand. | October 12–14, 1996 |
| Madeleine Korbel Albright | Pretoria, Cape Town | Met with President Mandela. | December 12–14, 1997 |
| Madeleine Korbel Albright | Cape Town, Pretoria | Met with President Mbeki and Foreign Minister Zuma; delivered addresses on public
health issues. | December 7–9, 2000 |
| Colin Luther Powell | Pretoria | Met with President Mbeki and delivered an address at Witwatersrand
University. | May 24–25, 2001 |
| Colin Luther Powell | Johannesburg | Attended the World Summit on Sustainable Development. | September 3–5, 2002 |
| Colin Luther Powell | Pretoria | Accompanied President Bush. | July 8–11, 2003 |
| Hillary Rodham Clinton | Johannesburg, Pretoria, Durban | Addressed an International Development Corporation event. Met with former
Presidents Mandela and de Klerk and with President Zuma. | August 7–9, 2009 |
| Hillary Rodham Clinton | Qunu, Johannesburg, Cape Town | Met with former President Nelson Mandela at Qunu. Attended U.S.-South Africa
Business Partnership Summit and U.S.-South Africa Strategic Dialogue Plenary Session in
Johannesburg. Met with Foreign Minister Maite Nekoana-Mashabane and AU Chair-Designate
Nkosazana Dlamini-Zuma. Participated in a PEPFAR Transition signing and met with former
President F.W. de Klerk in Cape Town. | August 6–9, 2012 |
| Antony Blinken | Pretoria | Launched the U.S. Strategy for Sub-Saharan Africa and led the U.S. delegation to
the U.S.-South Africa Strategic Dialogue. | August 7–9, 2022 |
