Chiefs of Mission for Uruguay
- Alexander Asboth (1867-1868)
- Henry Gaither Worthington (1868-)
- Robert C. Kirk (1869-1870)
- John Leavitt Stevens (1870-1873)
- John Curtis Caldwell (1874-)
- John Curtis Caldwell (1876-1882)
- Jeremiah McLain Rusk (1881-)
- William Williams (1882-1885)
- John Edmund Bacon (1885-)
- John Edmund Bacon (1886-1888)
- George Earl Maney (1889-)
- George Earl Maney (1890-1894)
- Granville Stuart (1894-1898)
- William Rufus Finch (1897-1905)
- Edward Charles O'Brien (1905-1909)
- Edwin Vernon Morgan (1909-1911)
- Nicolay Andrew Grevstad (1911-1914)
- John Longer de Saulles (1914-)
- Robert Emmett Jeffery (1915-1921)
- Hoffman Philip (1922-1925)
- Ulysses Grant-Smith (1925-1929)
- Leland Harrison (1929-1930)
- Joshua Butler Wright (1930-1934)
- George Strausser Messersmith (1934-)
- Julius Gareche Lay (1934-)
- Julius Gareche Lay (1935-1937)
- William Dawson (1937-)
- William Dawson (1937-1939)
- Edwin Carleton Wilson (1939-1941)
- William Dawson (1941-1946)
- Joseph F. McGurk (1946-1947)
- Williamson Smith Howell (1947-)
- Ellis Ormsbee Briggs (1947-1949)
- Christian Magelssen Ravndal (1949-1951)
- Edward L. Roddan (1951-1953)
- Dempster McIntosh (1953-1956)
- Jefferson Patterson (1956-1958)
- Robert Forbes Woodward (1958-1961)
- Edward John Sparks (1961-1962)
- Wymberley DeRenne Coerr (1962-1965)
- Henry Augustus Hoyt (1965-1967)
- Robert Marion Sayre (1968-1969)
- Charles Wallace Adair (1969-1972)
- Ernest Victor Siracusa (1973-1977)
- Lawrence A. Pezzulo (1977-1979)
- Lyle Francis Lane (1979-1980)
- Thomas Aranda (1981-1985)
- Malcolm Richard Wilkey (1985-1990)
- Richard C. Brown (1990-1993)
- Thomas J. Dodd (1993-1997)
- Christopher C. Ashby (1997-2001)
- Martin J. Silverstein (2001-2005)
- Frank Baxter (2006-2009)
- David Daniel Nelson (2009-2011)
- Julissa Reynoso (2012-)
- Norman Shaw Smith (-)
- Robert S. Gershenson (-)
- Lewis Wallace (-)