Chiefs of Mission for Spain
- John Jay (1779-)
- William Carmichael (1790-1794)
- William Short (1794-1795)
- David Humphreys (1796-1801)
- Charles Cotesworth Pinckney (1801-1804)
- James Bowdoin (1804-)
- George William Erving (1814-1819)
- John Forsyth (1819-1823)
- Hugh Nelson (1823-1825)
- Alexander Hill Everett (1825-1829)
- Cornelius Peter Van Ness (1829-1836)
- William Taylor Barry (1835-)
- John Henry Eaton (1836-1840)
- Aaron Vail (1840-1842)
- Washington Irving (1842-1846)
- Romulus Mitchell Saunders (1846-1849)
- Daniel Moreau Barringer (1849-1853)
- Pierre Soule (1853-1855)
- John Cabell Breckinridge (1855-)
- Augustus Caesar Dodge (1855-1859)
- William Preston (1858-1861)
- Carl Schurz (1861-1861)
- Cassius Marcellus Clay (1861-)
- Gustavus Koerner (1862-1864)
- John Parker Hale (1865-1869)
- Daniel Edgar Sickles (1869-)
- Caleb Cushing (1874-)
- James Russell Lowell (1877-1880)
- Lucius Fairchild (1880-1881)
- Hannibal Hamlin (1881-1882)
- John Watson Foster (1883-1885)
- Jabez Lamar Monroe Curry (1885-1888)
- Perry Belmont (1888-1889)
- Thomas Witherell Palmer (1889-1890)
- Edward Burd Grubb (1890-1892)
- Archibald Loudon Snowden (1892-1893)
- Hannis Taylor (1893-1897)
- Stewart Lyndon Woodford (1897-)
- Bellamy Storer (1899-1902)
- Arthur Sherburne Hardy (1902-1905)
- William Miller Collier (1905-1909)
- Henry Clay (1909-1913)
- Henry Clay Ide (1909-1913)
- Joseph Edward Willard (1913-)
- Joseph Edward Willard (1913-1921)
- Cyrus E. Woods (1921-1923)
- Alexander Pollock Moore (1923-1925)
- Ogden Haggerty Hammond (1925-1929)
- Irwin Boyle Laughlin (1929-1933)
- Claude Gernade Bowers (1933-1939)
- Alexander Wilbourne Weddell (1939-1942)
- Carlton Joseph Huntley Hayes (1942-1945)
- Norman Armour (1944-1945)
- Philip Wilson Bonsal (1946-1947)
- Stanton Griffis (1951-1952)
- Lincoln MacVeagh (1952-1953)
- James Clement Dunn (1953-1955)
- John Davis Lodge (1955-1961)
- Anthony Joseph Drexel Biddle (1961-1961)
- Robert Forbes Woodward (1962-1965)
- Angier Biddle Duke (1965-1968)
- Frank Edward McKinney (1968-)
- Robert Ferdinand Wagner (1968-1969)
- Robert Charles Hill (1969-1972)
- Horacio Rivero (1972-1974)
- Wells Stabler (1975-1978)
- Terence Alphonso Todman (1978-1983)
- Thomas Ostrom Enders (1983-1986)
- Reginald Bartholomew (1986-1989)
- Joseph Zappala (1989-1992)
- Richard Goodwin Capen (1992-1993)
- Richard Newton Gardner (1993-1997)
- Edward L. Romero (1998-2001)
- George L. Argyros (2001-2004)
- Eduardo Aguirre (2005-2009)
- Alan D. Solomont (2009-)
- Ellis Ormsbee Briggs (-)
- Harrison Freeman Matthews (-)
- Peter Magnus Flanigan (-)
- Paul Trauger Culbertson (-)
- Henry Shelton Sanford (-)
- William Starke Rosecrans (-)