Chiefs of Mission for Nicaragua
- Jonathan D. Farrar (-)
- John Bozman Kerr (1851-1853)
- John Slidell (1853-)
- Solon Borland (1853-1854)
- John H. Wheeler (1854-1856)
- Mirabeau Buonaparte Lamar (1857-)
- Mirabeau Buonaparte Lamar (1858-1859)
- Alexander Dimitry (1859-1861)
- Andrew B. Dickinson (1861-1863)
- Charles N. Riotte (1861-1867)
- Thomas Hart Clay (1862-1863)
- Andrew B. Dickinson (1863-1869)
- George McWillie Williamson (1873-)
- Cornelius Ambrose Logan (1879-)
- Henry Cook Hall (1882-)
- Henry Cook Hall (1882-1889)
- Lansing Bond Mizner (1889-1890)
- Romualdo Pacheco (1890-1891)
- Richard Cutts Shannon (1891-1893)
- Lewis Baker (1893-1897)
- William Lawrence Merry (1897-)
- William Lawrence Merry (-1908)
- John Gardner Coolidge (1908-1908)
- Horace Greeley Knowles (1909-)
- Elliott Northcott (1911-1911)
- George Thomas Weitzel (1911-1913)
- Benjamin Lafayette Jefferson (1913-1921)
- John Edward Ramer (1921-1925)
- Charles Christopher Eberhardt (1925-1929)
- Matthew Elting Hanna (1929-1933)
- Arthur Bliss Lane (1933-1936)
- Boaz Walton Long (1936-1938)
- Meredith Nicholson (1938-1941)
- Pierre de Lagarde Boal (1941-1942)
- James Bolton Stewart (1942-)
- James Bolton Stewart (1943-1945)
- William Fletcher Warren (1945-1947)
- George Price Shaw (1948-1949)
- Capus Miller Waynick (1949-1951)
- Thomas Edward Whelan (1951-1961)
- Aaron Switzer Brown (1961-1967)
- Kennedy McCampbell Crockett (1967-1970)
- Turner Blair Shelton (1970-1975)
- James Daniel Theberge (1975-1977)
- Mauricio Solaun (1977-1979)
- Lawrence A. Pezzulo (1979-1981)
- Anthony Cecil Eden Quainton (1982-1984)
- Harry Earl Bergold (1984-1987)
- Richard Huntington Melton (1988-)
- Harry Walter Shlaudeman (1990-1992)
- Ronald D. Godard (1992-1993)
- John F. Maisto (1993-1996)
- Lino Gutierrez (1996-1999)
- Oliver P. Garza (1999-2002)
- Barbara C. Moore (2002-2005)
- Paul A. Trivelli (2005-2008)
- Robert J. Callahan (2008-2011)
- Phyllis Marie Powers (2012-)
- Joseph Gerard Sullivan (-)
- John Hanaford Gregory (-)
- James Rudolph Partridge (-)
- Peter Michael McKinley (-)
- George Evans (-)