The United States recognized the Republic of the Comoros on August 15, 1977, when the United States and the Comorian Republic issued a joint communiqué that announced the establishment of diplomatic relations between the two countries.

Diplomatic relations were established on August 15, 1977, when United States and the Comorian Republic issued a joint communiqué that announced the establishment of diplomatic relations between the two countries. The first American Charge d’Affaires ad interim to the Republic of the Comoros, Robert S. Barrett IV, presented his credentials to Foreign Minister Mouzawior Abdallah on August 16, 1977. Barrett was also Charge d’Affairs ad interim and resident at Antananarivo, Madagascar.

The American Embassy at Moroni was established on August 26, 1985, with Edward Brynn as Chargé d'Affaires ad interim.

The American Embassy at Moroni was closed on September 30, 1993. Subsequent American Ambassadors to Comoros also have been accredited to Mauritius, and resident at Port Louis. On March 6, 2006, responsibilities for Comoros were transferred from Embassy Port Louis to Embassy Antananarivo.