Chiefs of Mission for Luxembourg
- Stanford Newel (1903-1905)
- David Jayne Hill (1905-1908)
- Arthur Matthias Beaupre (1908-1911)
- Lloyd Stephens Bryce (1911-1913)
- Henry van Dyke (1913-1917)
- John Work Garrett (1917-1919)
- William Phillips (1920-1922)
- Richard Montgomery Tobin (1923-)
- Henry Prather Fletcher (1923-1924)
- William Phillips (1924-1927)
- Hugh Simons Gibson (1927-1933)
- Dave Hennen Morris (1933-1937)
- Hugh Simons Gibson (1937-1938)
- Joseph Edward Davies (1938-1939)
- John Clarence Cudahy (1940-)
- Jay Pierrepont Moffat (1941-1943)
- Ray Atherton (1943-)
- Anthony Joseph Drexel Biddle (1943-)
- Rudolf Emil Schoenfeld (1944-1944)
- Charles Sawyer (1944-1945)
- Alan Goodrich Kirk (1946-1949)
- Perle (Pearl) Reid (Skirvin) Mesta (1949-1953)
- Wiley Thomas Buchanan (1953-)
- Wiley Thomas Buchanan (1956-1956)
- Vinton Chapin (1957-1960)
- Allingham Burks Summers (1960-1961)
- James Wilmer Wine (1961-1962)
- William Robert Rivkin (1962-1965)
- Patricia Roberts Harris (1965-1967)
- George Joseph Feldman (1967-1969)
- Kingdon Gould (1969-1972)
- Ruby Ruth (Lewis) Farkas (1973-1976)
- Rosemary Lucas Ginn (1976-1977)
- James Gordon Lowenstein (1977-1981)
- John Ernest Dolibois (1981-1985)
- Jean Broward Shevlin Gerard (1985-1990)
- Edward Morgan Rowell (1990-1994)
- Clay Constantinou (1994-1999)
- James Catherwood Hormel (1999-2001)
- Peter Terpeluk (2002-2005)
- Anne Louise Wagner (2005-2009)
- Cynthia Stroum (2009-2011)
- Robert A. Mandell (2011-)
- Winthrop Stephenson Greene (-)
- Frederick Morris Bush (-)
- George Platt Waller (-)
- George Platt Waller (-)